Although the entry of SARS-CoV-2 into the host cell is mediated via ACE2 receptor, the level of ACE2 receptors is downregulated following the infection, which likely increases the ACE–AngII–AT1 receptor axis and causes AngII-mediated detrimental effects, such as hypertension, thrombosis, and inflammation [48]. The gene discussed is AGT; the disease is Hypertension.