CXCL2 and infection: To improve the current GC therapy of sAH, it is imperative to understand the molecular mechanism of the differential regulation of hepatic expression of CXC chemokines CXCL1, CXCL2, and CXCL8 by sAH and GR, and the functional significance of the imbalanced CXC chemokines regarding the neutrophil function, liver injury/repair, and infections in sAH.