PKM and breast cancer: Using a LC-MS/MS protocol, pyruvate kinase M (PKM), an enzyme involved in HALLMARK_GLYCOLYSIS, metabolic reprogramming, cancer cell proliferation, adaptation to oxidative stress-induced apoptosis [112] and UDP-glucose 6-dehydrogenase (UGDH), involved in hyaluronic acid production and BC progression [113], have been found to be upregulated into a MCF7 BC cell line transfected for downregulation of jumping translocation breakpoint (JTB) protein [57].