Intermediate filament (IF) proteins, such as cytokeratins (CK), vimentin (VIM), the most abundant IF protein [87], and neuroepithelial stem cell protein (nestin/NES), are the largest families of cytoskeletal proteins assuring the structural integrity in cells and tissues, serving as diagnostic biomarkers in cancer cells that usually emphasize characteristic alterations in IF gene expression and protein regulation [88]. This evidence concerns the gene NES and cancer.