The anti-tumor effect of Glycyrrhizic acid has been reported in various types of tumors [16,17,18,19,20,21,22,23], through regulating several important signaling proteins, including those that belong to cysteine-dependent aspartate-specific protease (caspase) and the Bcl-2 families [24], the nuclear factor-kappa B (NF-κB) protein [25], the high mobility group box-1 (HMGB1) protein [26], the extracellular regulated protein kinases (ERK), the phosphatidylinositol 3-kinase (PI3K)/AKT kinases and the c-Jun N-terminal kinase (JNK) [24,27]. This evidence concerns the gene HMGB1 and neoplasm.