CASP8 and neoplasm: In addition, the anti-tumor effect of LQ has been reported in various types of tumor [16,27,28], through inducing cell cycle arrest and apoptosis via the ROS-mediated MAPK/AKT/NF-κB signaling pathway in hepatocellular carcinoma cells [16].LQ-triggered apoptosis was dependent on extrinsic and intrinsic pathways in cervical cancer cells through activation of Caspase-3 and poly ADP-ribose polymerase (PARP) cleavage, and Fas-associated protein with death domain (FADD)- and Bcl-2/Bax-regulated pathways, leading to Caspase-8 and Caspase-9 cleavage [27].