Regarding the prognostic utility of MMP-9 after stroke, in a study conducted by Sapojnikova et al. [67] it was reported that MMP-9 activation was significantly associated with a high MMP-9 plasma concentration in ischemic stroke patients, thus highlighting the fact that the levels of the active form of this proteolytic enzyme are elevated poststroke and play an important role in brain ischemia evolution. This evidence concerns the gene MMP9 and brain ischemia.