GADD45A and cancer: However, a comparison of the target genes for IK1-up and IK1-downregulated miRNAs showed hundreds of targets unique to either IK1 up- and IK1 down-regulated miRNAs (Table S6), including many which have recognized roles as oncogenes (e.g., KRAS, HRAS) and tumor suppressor genes (e.g., GADD45A, TP53, BRCA1, etc.)Among the unique target genes involved in cancer pathways is the ABL1 gene that is a target gene of hsa-miR-663a, which was up-regulated with IK1 growth suppression.