A recent study used mouse models to test genetic mutations associated with IBD to include nucleotide-binding oligomerization domain-containing protein 2 (NOD2), ATG16L1, recombination activating gene 2 (RAG2), interleukin 10 (IL-10) receptor deficiency, and nuclear factor kappa beta (NF-κB) essential modulator (NEMO) [18]. This evidence concerns the gene ATG16L1 and irritable bowel syndrome.