Existing case series suggest that there is considerable variability in the types and severity of neurodevelopmental problems associated with STXBP1 variants, and this study revealed that, compared to the other intellectual disability group with pathogenic mutations in other intellectual disability-associated genes, the STXBP1 group had more severe global adaptive impairments, fine motor difficulties, and hyperactivity [12]. The gene discussed is STXBP1; the disease is Intellectual disability.