COL2A1 and Stickler syndrome type 1: As genetic causes of congenital anomalies often affect both craniofacial structures and anterior segment development [41,42,43,44], it would be prudent to characterize the potential role for COL2A1 in these tissues to address gaps in our knowledge of the role of this protein in eye development and gain further insight into the pathogenesis of Stickler syndrome Type I.