Compared with uninjected and control-injected embryos (left and middle panels, Figure 4C), MO-injected Sox10-positive embryos showed skeletal defects, including scoliosis (upper right panel, dashed line, Figure 4C) and significantly shortened body length (Figure 4D), as well as severely delayed jaw and pharyngeal arch development (lower right-most panel, asterisk, Figure 4C). The gene discussed is SOX10; the disease is scoliosis.