“Metabolically healthy” obesity refers to individuals who do not suffer from cardio-metabolic abnormalities secondary to adiposity (hypertension, hypertriglyceridemia, low high-density lipoprotein [HDL] cholesterol, abnormal C-reactive protein (CRP), impaired fasting glucose and/or evidence of insulin resistance). Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.