Notably, LDHA was found to be expressed mainly in the central hypoxic area of the tumor (Fig 1C; Appendix Fig S1A), colocalized with carbonic anhydrase IX (CAIX or CA9; Appendix Fig S1B), and some cells invading the corpus callosum (CC), while LDHB was prevalently expressed in peripheral tumor areas and cells invading the CC (Fig 1C). Here, LDHA is linked to neoplasm.