In pancreatic cancer studies, it was found that the Shh signaling pathway promotes the process of EMT by affecting the components of various signaling pathways, including TGFβ, Ras, Wnt, PI3K/AKT, Integrin, and S100A4 (Xu et al., 2012). The gene discussed is S100A4; the disease is familial pancreatic carcinoma.