It was found that the reduced expressions of SIRT1, LXR, and FXR were associated with increased levels of lipid, alanine transaminase (ALT), alkaline phosphatase (ALP), and aspartate transaminase (AST) in rats with NAFLD, along with a significantly increased percentage of hepatocyte apoptosis (Hajighasem et al., 2013). Here, GPT is linked to metabolic dysfunction-associated steatotic liver disease.