Moreover, we examined the expression of other m6A enzymes upon overexpression of WTAP, and the results suggested that WTAP could not induce complementary effects of other m6A writers (Supplementary Figure S4).In conclusion, the therapeutic mechanism of APS involves regulating IL-6 expression through WTAP-mediated p65 nuclear translocation. Here, IL6 is linked to autoimmune polyendocrinopathy.