NMTP-5 can activate p53 signaling by targeting NRP1 into the cytoplasm of cancer cells, and at the same time interfere with MDM2-p53 interaction to up-regulate p53 levels and activate the expression of target genes that mediate cell cycle arrest and apoptosis in hepatocellular carcinoma (Zhou et al., 2021). This evidence concerns the gene TP53 and hepatocellular carcinoma.