In vivo and in vitro experiments (with the hepatoma cell line MHCC97H) also proved that BPS increased mRNA and protein levels for the epithelial markers E-cadherin and vesicular protein 1(VMP1), while inhibiting mRNA and protein levels for the interstitial markers N-cadherin (CDH2), vimentin and β-catenin (β-catenin). This evidence concerns the gene CDH2 and hepatocellular carcinoma.