CASP3 and liver cancer: It increased the expression of cleaved caspase-3 and the pro-apoptotic protein Bax, down-regulated the expression of the apoptosis inhibitory protein Bcl-2 in a dose-dependent manner and promoted the apoptosis of liver cancer cells, reducing the expression levels of PI3K, p-Akt, and NF-κB proteins (An et al., 2021).