WAP can enhance phagocytosis by macrophages, while ALP enhances the activation of lymphocytes to increase the release of cytokines such as interleukin -2 (IL-2), interleukin -12 (IL-12), interferon-gamma (IFN-γ) and TNF-α, which together induce the necrosis and apoptosis of tumor cells (Nazeam et al., 2017). This evidence concerns the gene TNF and neoplasm.