MSL2 and hepatocellular carcinoma: HBx can induce the up-regulation of male-specific lethal (MSL2) in stably transfected HBx hepatoma cell lines and HBx transgenic mice by activating yes-associated protein (Yap)/FoxA1 signaling, forming a positive feedback loop (HBx/MSL2/cccDNA/HBV) that regulates HBV cccDNA and promotes hepatocarcinogenesis (Gao et al., 2017).