HBx increases the expression of Smad-interacting protein 1 (SIP1) and recruits it to the promoter of E-cadherin to repress the transcription of E-cadherin, and the consequent decrease in E-cadherin expression blocks intercellular adhesion and attachment, thereby promoting tumor invasiveness (Ye et al., 2019). This evidence concerns the gene ZEB2 and neoplasm.