AKT1 and liver cancer: Erianin can reduce the proliferation, migration and invasion of liver cancer cells; down-regulate invasion-related proteins such as MMP-2, MMP-7, and MMP-9; promote cell apoptosis; and inhibit Akt and ERK/P38 phosphorylation in the PI3K/Akt and ERK/P38 pathways (Yang et al., 2020).