Evo up-regulates P53, Bcl2 and Bax; and down-regulates Bcl2, cyClinB1 and cdc2 proteins, significantly inducing G2/M cell cycle arrest in HepG2 cells, and inducing hepatocellular carcinoma cell apoptosis by inhibiting the NOD1 signaling pathway (Guo et al., 2018). Here, TP53 is linked to hepatocellular carcinoma.