Surprisingly, this research group also isolated and purified EPS364 from Vibrio alginolyticus 364, and not only confirmed that EPS364 showed anti-tumor effects that were similar to those of EPS11, but also that it possibly down-regulated the fibroblast growth factor 19 (FGF19)- fibroblast growth factor receptor 4 (FGFR4) signal axis. This evidence concerns the gene FGFR4 and neoplasm.