Lycorine not only induces G2/M cell cycle arrest in HepG2 cells by downregulating cyclin A, cyclin B1 and cell division cycle gene 2 (cdc2), but also inhibits the proliferation and migration of HepG2 hepatoblastoma cells by inhibiting Rho-associated coiled-coil containing protein kinase 1 (ROCK1)/cofilin-induced actin dynamics (Liu et al., 2019). This evidence concerns the gene ROCK1 and hepatoblastoma.