NR3C2 and endothelial dysfunction: It was reported that aldosterone-induced endothelial dysfunction and vascular remodeling are MR-dependent (Chen et al., 2019; Ferreira et al., 2021) and that aldosterone-induced aortic endothelium stiffness and impairment of EDR may associate with augmented activation of aortic EnNaC (Jia et al., 2018).