CRH and cancer: Since cancer anorexia and cachexia involve decreased ghrelin signaling due to excessive hypothalamic interactions of 5-HT with corticotropin-releasing factor through the 5-HT2cR (Fujitsuka et al., 2009), reported that the active components of XSLJZT, hesperidin and atractylodin, potentiate ghrelin secretion and receptor signaling, respectively, and atractylodin prolonged survival in tumor-bearing rats (Fujitsuka et al., 2011; Fujitsuka and Uezono, 2014).