The expression of YKL-40, Wnt4, β-catenin and TGF-β1 mRNA was significantly decreased after intervention in each administration group, suggesting that Cornus officinalis and its processed products may inhibit the development of DN and reduce the pathological changes of renal tissue by inhibiting Wnt/β-catenin signaling pathway. The gene discussed is WNT4; the disease is liver dysplastic nodule.