Serum syndecan-1 is a known indicator of vascular endothelial damage that correlates with coagulation disorders associated with sepsis prognoses, such as persistent thrombocytopenia and disseminated intravascular coagulation (DIC) (Ostrowski et al., 2015; Hatanaka et al., 2021). This evidence concerns the gene SDC1 and blood coagulation disease.