Among these targets, 37 genes were considered hub genes that were above the median values of BC-16.721506515, CC-0.704347826, DC-47, LAC-36.02462121, EC-0.104429837, and NC-40.10848235 (Figure 2B), which were associated with cellular response to oxidative stress, reactive oxygen species (ROS), and external stimulus predicted by GO analysis (Figure 2C), and were enriched in IL-17, TNF, HIF-1 signaling pathways, and colorectal cancer (Figure 2D). The gene discussed is HIF1A; the disease is colorectal cancer.