TRPA1 and cancer: TRPA1 is highly expressed in fibroblasts and has an important influence on many fibrotic diseases and pathological processes of cancers (Yin et al., 2018).As TRPA1 is a typical stress-responsive calcium/sodium channel, calcium channels can play a role in cell fibrosis through a series of signaling pathways, and a large amount of calcium influx can also lead to cell apoptosis.