Specifically, circRNA_09505 aggravated macrophage inflammation by promoting the production of inflammatory cytokines TNF-α, IL-6, IL-8, IL-12, and IL-1β through the miR-6089/AKT1/NF-κB axis, which is the most commonly deregulated cytokines in RA. This evidence concerns the gene CXCL8 and rheumatoid arthritis.