As results, the transcript levels of zebrafish inflammatory factors tnfa, il1b and il6 were all significantly increased after verapamil treatment and can be down-regulated by FJHQD, glycyrrhizic acid and licochalcone A. In addition, the expression of heart failure markers nppa, the caspase family of pro-inflammatory and apoptotic factors caspase 1 and caspase 3 also got a reduction after the treatment (Figure 8). Here, IL6 is linked to heart failure.