FJHQD and its active ingredients could significantly reduce the transcript levels of heart failure markers nppa, pro-inflammatory factors il1b, il6, tnfa, and the caspase family caspase 1, caspase 3, suggesting that FJHQD and its active ingredients may improve verapamil-induced decline in zebrafish cardiac function by regulating oxidative stress, inflammatory response and apoptosis-related pathways. This evidence concerns the gene CASP1 and heart failure.