The taurine pathway plays an antioxidant role in acute liver failure (Mizota et al., 2022), and it can inhibit liver injury and liver fibrosis by inhibiting TLR4/NFKB and (Younis et al., 2021) and TxNiP/NLRP3 (Yao et al., 2021) pathways. Here, TXNIP is linked to acute liver failure.