Podoplanin drives actomyosin contractility through the activation of RhoA/C GTPases in lymphoid fibroblasts (Martyn-Villar et al., 2006; Acton et al., 2014) and its high expression correlates with poor prognosis and higher incidence of metastatic disease (Quintanilla et al., 2019). This evidence concerns the gene PDPN and metastatic neoplasm.