PDE4B and cancer: The results of previous studies have demonstrated that high expression of PDE4B was involved in inflammatory processes in several organs of the body and thus in the development of cancer, including hematologic malignancies (Kim et al., 2019), colon (Komatsu et al., 2013), and lung (Azam and Tripuraneni, 2014), and related results have demonstrated the important role of PDE4B in inflammation (Ma et al., 2014) (Table 1).