CDKN2B and breast cancer: Ginsenoside Rg5 can also induce G0/G1 cell cycle arrest by reducing the protein expression of cyclin D1, cyclin E2 and CDK4, and increasing the expression of p15 ink 4B, p53 and p21WAF1/CIP1, and subsequently inhibit the proliferation of BC cells (Kim and Kim 2015).