In details, ginsenoside Rg2 can induce ROS production by inhibiting the activation of ERK1/2 and Akt, which in turn inhibits proliferation of BC cells, further arrest the cell cycle of G1 and induce apoptosis of BC cells by promoting ROS-mediated AMPK activation (Jeon et al., 2021b). Here, MAPK3 is linked to breast cancer.