NFKB1 and infection: After infection with SARS-COV-2, the innate immune system is triggered, and various inflammatory pathways are activated, among which NLRP/IL-1β, JAK/STAT, TNF-α/NF-κB, and other pathways have been confirmed to be closely related to SARS-CoV-2 infection (Jiang et al., 2020).