Hyperglycemia also stimulates the transcription nuclear factor (NF-κB), which in turn causes overexpression of specific gene sequences that control the regulation of numerous inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), and cyclooxygenase-2 (COX-2) (Ahmed et al., 2016). This evidence concerns the gene NFKB1 and Hyperglycemia.