ABCC2 and cancer: Thus, altered ABCC2 functioning owing to ABCC2 single nucleotide polymorphisms (SNPs) can change the clearance, organ distribution, and absorption of several clinically important drugs, including antibiotics (e.g., ceftriaxone, rifampicin, and ampicillin), toxins, anti-hyperlipidemia inhibitors, and several cancer chemotherapy drugs (e.g., MTX, vinblastine, and irinotecan) (Jemnitz et al., 2010).