Several studies have shown that ABCC2 SNPs mediate the efflux of irinotecan, cisplatin, and methotrexate from intracellular to extracellular spaces in colorectal cancer, ovarian cancer, and acute lymphoblastic leukemia (Corpechot et al., 2020; Huang et al., 2021). This evidence concerns the gene ABCC2 and colorectal cancer.