The down-regulated LncRNA PVT1, LncRNA CACS2, and LncRNA UCA1 could, respectively, regulate the downstream proteins including BDNF, PTEN, or JAK to promote the activation of astrocytes and the progression of epilepsy (Zhao et al., 2019; Wang et al., 2020; Zhu et al., 2020). This evidence concerns the gene PVT1 and epilepsy.