Transfection of pcDNA- ZFAS1 could promote apoptosis (He et al., 2021), while knockdown of ZFAS1 could inhibit the apoptosis and autophagy of hippocampal neurons by activating the PI3K/AKT pathway via up-regulating miR-421 in epilepsy (Hu et al., 2020). The gene discussed is ZFAS1; the disease is epilepsy.