Since PSP is usually associated with tauopathy, while svPPA and ALS are associated with TDP-43 proteinopathy, in this study, pRNFL and macular thickness were used to compare patients with PSP (presumed tauopathy) to those with svPPA or ALS (presumed TDP-43 proteinopathy). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.