TARDBP and proteostasis deficiencies: Some FTLD-related syndromes, such as progressive supranuclear palsy (PSP), are reliably associated with tauopathy (Höglinger et al., 2017; Kim et al., 2019), while semantic variant primary progressive aphasia (svPPA) is almost always associated with TDP-43 proteinopathy (Irwin et al., 2015).