Lipoxygenases oxidize arachidonic acid to generate HETEs (Figure 1B).22, 23, 24 5-HETE is generated from 5-lipoxygenase (ALOX5); ALOX5 inhibition has been shown to slow the growth of cancer cells in vitro.25, 26, 27 The role of eicosanoid 15-HETE, on the other hand, is less clear, as it has been implicated in both protumorigenic and antitumorigenic roles.28 Here, ALOX5 is linked to cancer.