On further assessment of the correlations among CDX2 and clinical pathological parameters, we suggested that CDX2 was meaningfully related to tumor size (<3 cm and ≥3; P < 0.05), depth grading of tumor invasion (T1+T2 and T3+T4; P < 0.05), and lymph node status (N0 and N1 + N2; P < 0.01) (Table S3). Here, CDX2 is linked to neoplasm.