Notably, our signature model demonstrated that the risk score was positively correlated with the infiltration levels of certain immune cells, including aDCs/iDCs/DCs, CD8+ T cells, Mccrophages, Tfh, Th1/Th2 cells, TIL and Treg, indicating that oxidative stress-related DElncRNA signature might serve as a key role in immune cell infiltration in HCC. Here, CD8A is linked to hepatocellular carcinoma.