INS and Hyperinsulinemia: T2DM will cause patients hyperinsulinemia, which will increase risk of EC by adjusting serum levels of IGF1.The hyperinsulinemia results in a constant increase in serum insulin levels among T2DM patients, which decreases the levels of growth factor binding protein 1(IGFBR 1) and IGFBP 2.Those effects lead to the rise of IGF1 in blood, which increases risk of EC [61].