Among them, the key targets of seven chronic liver diseases included PIK3CA and MAPK1, and the key targets of six diseases included PIK3R1, SRC, AKT1, STAT3, and MAPK3, indicating that these seven targets had an essential role in the inflammation-carcinoma transformation of QBD in the treatment of chronic liver diseases. The gene discussed is MAPK3; the disease is carcinoma.