TCF4 and hypertensive disorder: In addition, genes from GreenYellow, which were found to have the highest association with uncontrolled hypertension (r = 0.35, p = 0.03, soft threshold beta = 12, Figures 7A,B) were involved in hemostasis, smooth muscle contraction, regulation of cell adhesion, Ras protein signal transduction, and so on, which were broadly regulated by SRF and TCF4.