HDAC4 and myocardial infarction: Additionally, GWAS have associated single nucleotide polymorphisms (SNPs) in miR-140-5p gene targets such as SEPT2 (SEPTIN2) with T1DM (76), DNMT1 with CVD (77) and HDAC4 with increased susceptibility to myocardial infarction following coronary artery bypass surgery (78).