GWAS also showed that variants in CDKN1A are associated with ischemic strokes (64), atrial fibrillation and cardioembolic stroke (65), while variants in other experimentally validated gene targets of mir-423-3p; PA2G4 are associated with BMI (66) and BCL2L11 with T2DM and cholesterol levels (67). The gene discussed is PA2G4; the disease is cardioembolic stroke.