Additionally, GWAS have associated single nucleotide polymorphisms (SNPs) in miR-140-5p gene targets such as SEPT2 (SEPTIN2) with T1DM (76), DNMT1 with CVD (77) and HDAC4 with increased susceptibility to myocardial infarction following coronary artery bypass surgery (78). The gene discussed is HDAC4; the disease is type 1 diabetes mellitus.