MiR-204 has been found to be downregulated in diseased pulmonary arterial smooth muscle cells (PASMCs) in PAH and is linked to signaling molecules crucial to PAH including PPAR-γ, TGF-β1, STAT3, SHP2, BRD4, NFAT, and HIF-1α (20, 30, 31). The gene discussed is PTPN11; the disease is pulmonary arterial hypertension.