For example, has been demonstrated that deficient mice for Gopc (Golgi-associated PDZ- and coiled-coil motif-containing protein) that is a Golgi-associated protein and for Agfg1, that is required for docking and/or fusion of pro-acrosomic vesicles during acrosome biogenesis, are infertile due to globozoospermia (65). The gene discussed is AGFG1; the disease is Infertility.