NDUFS1 and polycystic ovary syndrome: The expression of Sirtuin 3 (SIRT3) was significantly reduced in GCs of PCOS patients, while the knockdown of SIRT3 could change the acetylation state of NDUFS1, which may induce mitochondrial dysfunction, elevated oxidative stress, and glucose metabolism defects, leading to damage of oocytes in PCOS (63).