Quantitative analysis of acetylation proteomics in PCOS and control ovarian GCs by mass spectrometry showed that the acetylation level was increased in the PCOS group, and the acetylation level of Acetyl-CoA acetyltransferase 1 (ACAT1) in clinical PCOS GCs was negatively correlated with oocyte quality and embryo development efficiency (58). The gene discussed is ACAT1; the disease is polycystic ovary syndrome.