KDM6B and polycystic ovary syndrome: In PCOS mice with nonalcoholic fatty liver, androgens decrease the expression of core clock gene promoters by inhibiting the expression of the histone methyltransferase Ezh2 while inducing the expression of the histone demethylase JMJD3 Silences the expression of the marker H3K27me3, for which the expression of JMJD3 is responsible for the addition or deletion of the H3K27me3 marker (47).