Intralesional injection of recombinant murine adiponectin into hypervascularized murine fibrocarcinomas led to a 60% reduction in tumor volumes and weights accompanied by an increase in tumor apoptosis mediated through caspase-3 activation, which suggests that adiponectin could act as a potent angiogenesis inhibitor that can activate apoptosis, and thus inhibit tumor growth (11). This evidence concerns the gene CASP3 and neoplasm.