MAPT and early-onset autosomal dominant Alzheimer disease: Aging causes increased production of ROS, disruption of BBB, exacerbated Aβ production, and neuroinflammation, which causes pathogenesis of both Alzheimer’s disease and COVID-19 [48]. Also, ischemic white matter damage [49], Blood-Brain Barrier damage, cerebral hypoperfusion, which increases the phosphorylation of tau protein [50], and cerebral accumulation of Aβ amyloid is potentiated by COVID-19 and potentially favor Alzheimer’s disease development [51].