In view of the paucity of our knowledge and with the aim to partially cover this gap, the present study is the first report of a retrospective cohort study that represents the incidence of BRAF V600E gene mutation in malignant melanoma and CRC development and its correlation with sex and age, within the Lebanese population by using real-time polymerase chain reaction (PCR) technique at the pathologic department with a view to modifying the therapeutic approach and follow-up. This evidence concerns the gene BRAF and melanoma.