BRAF and colorectal cancer: B-type rapidly accelerated fibrosarcoma (BRAF) kinase gene mutation is a B-viral oncogene that was first discovered to be somatically mutated in 2002 and seen in up to 15% of many human malignancies [1], including 40% to 80% of all types of malignant melanoma [2,3] and 9% to 15% of colorectal cancers (CRCs) [4], as well as many other tumors and some inflammatory diseases.