Likewise, there is evidence of age-dependent LTM impairment accompanied by overactivation of ERK1 in the medial prefrontal cortex of the triple transgenic mice (3xTg), an animal model of Alzheimer disease (AD) expressing PS1M146V, APPSwe, and tauP301L transgenes (Oddo et al., 2003), in which local ERK inhibition rescues recognition memory deficits (Feld et al., 2014). Here, MAPK1 is linked to Alzheimer disease.