RLN3 and Anxiety: In rodents the RLN3/RXFP3 signaling system, with RLN3 neurons originating in the NI, has been implicated in the control of food intake, stress responses (including freezing), anxiety, addiction, locomotor activity, memory, and other arousal-related behaviors (Ma et al., 2013; Pereira et al., 2013; Blasiak et al., 2017; Kumar et al., 2017).