The broad expression of Rxfp3 in the brain is in line with suggested roles for Rln3/Rxfp3 signaling in modulation of stress responses, appetite, feeding and metabolism, motivation and reward, exploratory navigation, emotion (anxiety) and social recognition, memory and cognition, and sleep and circadian rhythm (Sutton et al., 2004; Gundlach et al., 2009; Smith et al., 2010; Tanaka, 2010; Callander et al., 2012; Ganella et al., 2013; Ma et al., 2013, 2017; Ryan et al., 2013; Kumar et al., 2017; de Ávila et al., 2018; Albert-Gasco et al., 2019; Kania et al., 2020). This evidence concerns the gene RXFP3 and Anxiety.