Tuberous Sclerosis Complex (TSC) is a genetic disorder affecting ~1 million patients worldwide and is caused by inactivating mutations in TSC1 or TSC2 (Osborne et al., 1991; The European Chromosome 16 Tuberous Sclerosis Consortium, 1993; Van Slegtenhorst et al., 1997; O’Callaghan et al., 1998; Feliciano et al., 2013a; Feliciano, 2020; Northrup et al., 2021; Strzelczyk et al., 2021). This evidence concerns the gene TSC1 and hereditary disease.