TRPM8 and migraine disorder: Genome-wide association analysis have revealed that TRPM8 is associated with susceptibility to migraine without aura (Freilinger et al., 2012), and reduced TRPM8 expression (rs10166942 carriers) helps reduce migraine risk in humans (Gavva et al., 2019), which may provide the rationale for the topical menthol as an alternative treatment option for migraine patients.