Andersen et al. (2017) conducted a similar study and got the same conclusion, further verified the antipruritic effect of menthol like doxepin. Using a combination of pharmacologic, genetic, and mouse behavioral assays, Palkar et al. (2018) found that the inhibition of pruritus by menthol requires TRPM8 channels or intact and functional TRPM8-expressing afferent neurons. Here, TRPM8 is linked to Pruritus.