Furthermore, another interactor ADHC1 (AT-hook DNA-binding motif-containing protein 1, MIM 615790) is involved in Xia-Gibbs syndrome with symptoms of ID, speech/motor delay, and facial dysmorphism (Xia et al., 2014), whereas interactor CHD3 is associated with Snijders Blok-Campeau syndrome, an NDD exhibiting macrocephaly and speech/language delay (Snijders Blok et al., 2018). This evidence concerns the gene AHDC1 and Macrocephaly.