Missense variants of the interactor CDC42 cause a diverse neurodevelopmental phenotype resembling Noonan syndrome (Martinelli et al., 2018), and the interactor SETD1B (aka KMT2G) is associated with the syndromic ID (Hiraide et al., 2018; Roston et al., 2021; Weerts et al., 2021; Table 2). This evidence concerns the gene CDC42 and Noonan syndrome.